Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Resea

Gene expression in breast cancer provides valuable biological information for better determining the diagnosis, treatment, risk of relapse and survival rate. However, the most common form of characterizing breast cancer is by histopathological techniques. This study, headed by Dr Aleix Prat, Head of

Obese, postmenopausal women are at greater risk for developing breast cancer and their cancers tend to be more aggressive than those in lean counterparts. A University of Colorado Cancer Center study published in the December issue of the journal Cancer Research shows how this risk might be prevente

More patients can benefit from highly effective breast cancer drugs that are already available, according to DNA sequencing studies by researchers at Washington University School of Medicine in St. Louis and other institutions. The investigators found that some women with the HER2 negative subtype

Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer tre

The DNA mutations that accumulate over time as women age are not the sole contributor to the higher frequency of breast cancer in women over 50, Mark LaBarge, PhD, a researcher at Lawrence Berkeley National Laboratory (LBNL) reported on Dec. 17 in a presentation at the American Society for Cell Biol

Researchers at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory have put the squeeze - literally - on malignant mammary cells to guide them back into a normal growth pattern. The findings, presented Monday, Dec. 17, at the annual meeting of the American Society

A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth. The findings, published online in Oncogene, focus on the gene BRCA1, which is mutated in a majority of families who have hereditary breast a

Human breast cancer cells growing in the lab on a three-dimensional (3-D) extracellular matrix reverted to a normal phenotype when subjected to compression force applied by an elastic chamber, researchers reported on Dec. 17 at the American Society for Cell Biology Annual Meeting in San Francisco.

Tumor metastasis, which accounts for the majority of deaths in breast cancer patients, is a process by which cancer cells acquire the ability to invade tissue and survive in other parts of the body. Dysregulation of the protein TGF-β is known to drive breast cancer metastasis, but the precise molecu